MersV1, Istex, Checkpoint, bibRecord, 001033

In vitro selection of nucleic acids for diagnostic applications

Identifieur interne : 001033 ( Istex/Checkpoint ); précédent : 001032; suivant : 001034

In vitro selection of nucleic acids for diagnostic applications

Auteurs : Jay Hesselberth [États-Unis] ; Michael P. Robertson [États-Unis] ; Sulay Jhaveri [États-Unis] ; Andrew D. Ellington [États-Unis]

Source :

Reviews in Molecular Biotechnology [ 1389-0352 ] ; 2000.

RBID : ISTEX:A1BCB879F672C56817EBFD939F6E0DE1A16B0549

English descriptors

KwdEn :
- Aptamer, Aptazyme, Diagnostics, In vitro selection, Signaling aptamer.
Teeft :
- Activation parameters, Allosteric, Allosteric ribozyme, Aptamer, Aptamers, Aptazyme, Aptazymes, Assay, Base pair, Biol, Biotechnology, Breaker, Catalysis, Catalytic activity, Chem, Cognate, Cognate ligand, Diagnostic applications, Dynamic range, Effector, Ellington, Elsevier science, Hammerhead, Hammerhead ribozyme, Hesselberth, Iews, Internal loop, Ligand, Ligase, Molecular biotechnology, Nucleic, Nucleic acids, Nucleotide, Oligonucleotide, Oligonucleotide tags, Patel, Peptide, Random sequence population, Ribozyme, Ribozymes, Uorescence, Uorescence intensity, Uorescent, Variant ribozymes, Wide range.

Abstract

Abstract: In vitro selection methods have proven to be extraordinarily adept at generating a wide variety of nucleic acid-binding species (aptamers) and catalysts (ribozymes). To date, selected nucleic acids have primarily been of academic interest. However, just as antibodies have proven utility as ‘universal receptors’ that can be crafted against a huge variety of ligands and can be readily adapted to diagnostic assays, aptamers may yet find application in assays. A new class of research reagents, aptazymes, are not mere mimics of antibodies but in fact allow the direct transduction of molecular recognition to catalysis. Aptamers and aptazymes may prove to be uniquely useful for the development of chip arrays for the detection and quantitation of a wide range of molecules in organismal proteomes and metabolomes.

Url:

https://api.istex.fr/ark:/67375/6H6-J2DH9S9V-C/fulltext.pdf

DOI: 10.1016/S1389-0352(99)00005-7

Affiliations:

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Le document en format XML

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<term>Random sequence population</term>
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<term>Ribozymes</term>
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<front><div type="abstract" xml:lang="en">Abstract: In vitro selection methods have proven to be extraordinarily adept at generating a wide variety of nucleic acid-binding species (aptamers) and catalysts (ribozymes). To date, selected nucleic acids have primarily been of academic interest. However, just as antibodies have proven utility as ‘universal receptors’ that can be crafted against a huge variety of ligands and can be readily adapted to diagnostic assays, aptamers may yet find application in assays. A new class of research reagents, aptazymes, are not mere mimics of antibodies but in fact allow the direct transduction of molecular recognition to catalysis. Aptamers and aptazymes may prove to be uniquely useful for the development of chip arrays for the detection and quantitation of a wide range of molecules in organismal proteomes and metabolomes.</div>
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In vitro selection of nucleic acids for diagnostic applications

In vitro selection of nucleic acids for diagnostic applications

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

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